Lupan-3β,20-diol synthase (EC 4.2.1.128, LUP1 (gene)) is an enzyme with systematic name (3S)-2,3-epoxy-2,3-dihydrosqualene hydro-lyase (lupan-3beta,20-diol forming).[1][2] This enzyme catalyses the following chemical reaction
| Lupan-3β,20-diol synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 4.2.1.128 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
- lupan-3β,20-diol (3S)-2,3-epoxy-2,3-dihydrosqualene + H2O
The reaction occurs in the reverse direction.
References
edit- ^ Segura MJ, Meyer MM, Matsuda SP (July 2000). "Arabidopsis thaliana LUP1 converts oxidosqualene to multiple triterpene alcohols and a triterpene diol". Organic Letters. 2 (15): 2257–9. doi:10.1021/ol006016b. PMID 10930257.
- ^ Kushiro T, Hoshino M, Tsutsumi T, Kawai K, Shiro M, Shibuya M, Ebizuka Y (November 2006). "Stereochemical course in water addition during LUP1-catalyzed triterpene cyclization". Organic Letters. 8 (24): 5589–92. doi:10.1021/ol062310d. PMID 17107079.
External links
edit- Lupan-3beta,20-diol+synthase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
