Lyne is a surname, and may refer to
- Adrian Lyne, British film maker
- Andrew Lyne, British physicist
- Becky Lyne, British middle-distance runner
- Carmichael Lyne, Australian politician
- Charlie Lyne, British film journalist
- Joseph Leycester Lyne, British Anglican preacher and promoter of monasticism
- Lanham Lyne, Texas politician
- William Lyne, Australian politician