Lysobisphosphatidic acid (LBPA) (also known as bis(monoacylglycero)phosphate (BMP)) is a phospholipid that is found in the membranes of late endosomes and lysosomes of eukaryotic cells.
Phosphatidylglycerol is a precursor and structural isomer of LBPA.[1] LBPA's stereochemistry is atypical among glycerophospholipids and influences its function within the LE/LY (late endosome/lysosome) system.[1][2]
LBPA makes up 15–20% of all LE/LY phospholipids and is not found in other subcellular membranes.[3] LBPA is primarily found within the inner LE/LY membranes where they play a role in their structure and trafficking processes.[1][2] In particular, an interaction between NPC2 and LBPA is necessary for intracellular cholesterol trafficking.[1]
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edit- ^ a b c d McCauliff, Leslie A; Langan, Annette; Li, Ran; Ilnytska, Olga; Bose, Debosreeta; Waghalter, Miriam; Lai, Kimberly; Kahn, Peter C; Storch, Judith (3 October 2019). "Intracellular cholesterol trafficking is dependent upon NPC2 interaction with lysobisphosphatidic acid". eLife. 8: e50832. doi:10.7554/eLife.50832. ISSN 2050-084X. PMC 6855803. PMID 31580258.
- ^ a b Goursot, A.; Mineva, T.; Bissig, C.; Gruenberg, J.; Salahub, D. R. (2 December 2010). "Structure, Dynamics, and Energetics of Lysobisphosphatidic Acid (LBPA) Isomers". The Journal of Physical Chemistry B. 114 (47): 15712–15720. doi:10.1021/jp108361d. ISSN 1520-6106. PMID 21053942. Retrieved 9 October 2023.
- ^ Ilnytska, Olga; Jeziorek, Maciej; Lai, Kimberly; Altan-Bonnet, Nihal; Dobrowolski, Radek; Storch, Judith (June 2021). "Lysobisphosphatidic acid (LBPA) enrichment promotes cholesterol egress via exosomes in Niemann Pick type C1 deficient cells". Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1866 (6): 158916. doi:10.1016/j.bbalip.2021.158916. ISSN 1388-1981. PMC 8038758. PMID 33716137.