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The M23 RNA motif is a conserved RNA structure that was discovered by bioinformatics.[1] M23 motif RNAs are found in Clostridia.
| M23 | |
|---|---|
 Consensus secondary structure and sequence conservation of M23 RNA | |
| Identifiers | |
| Symbol | M23 |
| Rfam | RF03006 |
| Other data | |
| RNA type | Gene; sRNA |
| SO | SO:0001263 |
| PDB structures | PDBe |
M23 RNAs are generally located upstream of protein-coding genes, and therefore they might function as cis-regulatory elements. Most M23 RNAs are located upstream of M23 peptidase genes, but one is upstream of a gene whose product is NAD synthetase. However, there were two cases where no downstream gene was located.[1] While these cases had technical explanations not related to biology,[1] it is possible they the technical explanations do not apply, and that the M23 RNA motif functions as a small RNA.
An M23 RNA was observed to apparently bind a molecule in yeast extract.[1] However, this putative molecule has not (as of 2018) been identified.
References
edit- ^ a b c d Weinberg Z, Lünse CE, Corbino KA, Ames TD, Nelson JW, Roth A, et al. (October 2017). "Detection of 224 candidate structured RNAs by comparative analysis of specific subsets of intergenic regions". Nucleic Acids Research. 45 (18): 10811–10823. doi:10.1093/nar/gkx699. PMC 5737381. PMID 28977401.