M7GpppN-mRNA hydrolase (EC 3.6.1.62, DCP2, NUDT16, D10 protein, D9 protein, D10 decapping enzyme, decapping enzyme) is an enzyme with systematic name m7GpppN-mRNA m7GDP phosphohydrolase.[1][2][3][4][5][6][7] This enzyme catalyses the following chemical reaction
| M7GpppN-mRNA hydrolase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.6.1.62 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
- m7G5'ppp5'-mRNA + H2O m7GDP + 5'-phospho-mRNA
Decapping of mRNA is essential in eukaryotic mRNA turnover.
References
edit- ^ Xu J, Yang JY, Niu QW, Chua NH (December 2006). "Arabidopsis DCP2, DCP1, and VARICOSE form a decapping complex required for postembryonic development". The Plant Cell. 18 (12): 3386–98. doi:10.1105/tpc.106.047605. PMC 1785416. PMID 17158604.
- ^ Lu G, Zhang J, Li Y, Li Z, Zhang N, Xu X, Wang T, Guan Z, Gao GF, Yan J (January 2011). "hNUDT16: a universal decapping enzyme for small nucleolar RNA and cytoplasmic mRNA". Protein & Cell. 2 (1): 64–73. doi:10.1007/s13238-011-1009-2. PMC 4875290. PMID 21337011.
- ^ van Dijk E, Cougot N, Meyer S, Babajko S, Wahle E, Séraphin B (December 2002). "Human Dcp2: a catalytically active mRNA decapping enzyme located in specific cytoplasmic structures". The EMBO Journal. 21 (24): 6915–24. doi:10.1093/emboj/cdf678. PMC 139098. PMID 12486012.
- ^ Parrish S, Resch W, Moss B (February 2007). "Vaccinia virus D10 protein has mRNA decapping activity, providing a mechanism for control of host and viral gene expression". Proceedings of the National Academy of Sciences of the United States of America. 104 (7): 2139–44. Bibcode:2007PNAS..104.2139P. doi:10.1073/pnas.0611685104. PMC 1793903. PMID 17283339.
- ^ Soulière MF, Perreault JP, Bisaillon M (April 2009). "Characterization of the vaccinia virus D10 decapping enzyme provides evidence for a two-metal-ion mechanism". The Biochemical Journal. 420 (1): 27–35. doi:10.1042/BJ20082296. PMID 19210265.
- ^ Parrish S, Moss B (December 2007). "Characterization of a second vaccinia virus mRNA-decapping enzyme conserved in poxviruses". Journal of Virology. 81 (23): 12973–8. doi:10.1128/JVI.01668-07. PMC 2169080. PMID 17881455.
- ^ Song MG, Li Y, Kiledjian M (November 2010). "Multiple mRNA decapping enzymes in mammalian cells". Molecular Cell. 40 (3): 423–32. doi:10.1016/j.molcel.2010.10.010. PMC 2982215. PMID 21070968.
External links
edit- M7GpppN-mRNA+hydrolase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
