MAGEA10

MAGEA10 (MAGE family member A10) is a protein-coding gene in humans clustered at chromosomal location Xq28.

MAGEA10
Identifiers
Aliases	MAGEA10, CT1.10, MAGE10, MAGE family member A10
External IDs	OMIM: 300343; MGI: 3588211; HomoloGene: 121621; GeneCards: MAGEA10; OMA:MAGEA10 - orthologs
Gene location (Human) Chr. X chromosome (human) Band Xq28 Start 152,133,310 bp End 152,138,578 bp
Gene location (Mouse) Chr. X chromosome (mouse) Band X|X A7.3 Start 71,425,476 bp End 71,430,464 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle placenta gonad right testis left testis renal cortex urinary bladder vagina ectocervix gallbladder Top expressed in primary oocyte zygote secondary oocyte blastocyst spermatid spermatocyte testicle More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 4109 236852 Ensembl ENSG00000124260 ENSMUSG00000043453 UniProt P43363 A2AMW4 RefSeq (mRNA) NM_021048 NM_001011543 NM_001251828 NM_001085506 RefSeq (protein) NP_001011543 NP_001238757 NP_066386 NP_001078975 Location (UCSC) Chr X: 152.13 – 152.14 Mb Chr X: 71.43 – 71.43 Mb PubMed search
Wikidata
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Function

This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls.

The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream melanoma antigen family A, 5 (MAGEA5) gene.

Further reading

• Lin J, Lin L, Thomas DG, Greenson JK, Giordano TJ, Robinson GS, Barve RA, Weishaar FA, Taylor JM, Orringer MB, Beer DG (2004). "Melanoma-associated antigens in esophageal adenocarcinoma: identification of novel MAGE-A10 splice variants". Clin. Cancer Res. 10 (17): 5708–16. doi:10.1158/1078-0432.CCR-04-0468. PMID 15355897.
• Schultz-Thater E, Piscuoglio S, Iezzi G, Le Magnen C, Zajac P, Carafa V, Terracciano L, Tornillo L, Spagnoli GC (2011). "MAGE-A10 is a nuclear protein frequently expressed in high percentages of tumor cells in lung, skin and urothelial malignancies". Int. J. Cancer. 129 (5): 1137–48. doi:10.1002/ijc.25777. PMID 21710496.
• Badovinac Črnjević T, Tanja BČ, Spagnoli G, Giulio S, Juretić A, Antonio J, Jakić-Razumović J, Jasminka JR, Podolski P, Paula P, Šarić N, Nera Š (2012). "High expression of MAGE-A10 cancer-testis antigen in triple-negative breast cancer". Med. Oncol. 29 (3): 1586–91. doi:10.1007/s12032-011-0120-9. PMID 22116775. S2CID 22748757.
• Wang L, Xu Y, Luo C, Sun J, Zhang J, Lee MW, Bai A, Chen G, Frenz CM, Li Z, Huang W (2015). "MAGEA10 gene expression in non-small cell lung cancer and A549 cells, and the affinity of epitopes with the complex of HLA-A(∗)0201 alleles". Cell. Immunol. 297 (1): 10–8. doi:10.1016/j.cellimm.2015.05.004. PMID 26058806.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.