Melanoma-associated antigen 4 is a protein that in humans is encoded by the MAGEA4 gene.[3][4]

MAGEA4
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesMAGEA4, CT1.4, MAGE-41, MAGE-X2, MAGE4, MAGE4A, MAGE4B, MAGE family member A4
External IDsOMIM: 300175; HomoloGene: 134073; GeneCards: MAGEA4; OMA:MAGEA4 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001011548
NM_001011549
NM_001011550
NM_002362

n/a

RefSeq (protein)

NP_001011548
NP_001011549
NP_001011550
NP_002353

n/a

Location (UCSC)Chr X: 151.91 – 151.93 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls.

Clinical importance

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The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. At least four variants encoding the same protein have been found for this gene.[4]

In salivary gland carcinomas, MAGE4 expression correlates to lower-grade histology, lower likelihood of metastases and more favourable survival.[5]

While MAGEA4 is expressed by many tumours,[6] it is almost universally expressed by synovial sarcomas.[7] A targeted treatment to use genetically modified autologous T cells is (as of June 2021) undergoing clinical trials.[8]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000147381Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ Rogner UC, Wilke K, Steck E, Korn B, Poustka A (October 1995). "The melanoma antigen gene (MAGE) family is clustered in the chromosomal band Xq28". Genomics. 29 (3): 725–31. doi:10.1006/geno.1995.9945. PMID 8575766.
  4. ^ a b "Entrez Gene: MAGEA4 melanoma antigen family A, 4".
  5. ^ Vital D, Ikenberg K, Moch H, Roessle M, Huber GF (June 2018). "The expression of the cancer testis antigen MAGE A4: A favorable prognostic biomarker in salivary gland carcinomas related to low tumor grading". Laryngoscope Investigative Otolaryngology. 3 (3): 182–190. doi:10.1002/lio2.160. PMC 6057220. PMID 30062133.
  6. ^ Yakirevich E, Sabo E, Lavie O, Mazareb S, Spagnoli GC, Resnick MB (December 2003). "Expression of the MAGE-A4 and NY-ESO-1 cancer-testis antigens in serous ovarian neoplasms". Clinical Cancer Research. 9 (17): 6453–60. PMID 14695148.
  7. ^ "Specific Peptide-Enhanced Affinity Receptor MAGE-A4 T Cells for Synovial Sarcoma". www.healio.com. Retrieved 2021-07-02.
  8. ^ Hong DS, Butler MO, Johnson M, Olszanski AJ, Norry E, Van Winkle E, et al. (October 2018). "Initial safety assessment of MAGE-A4 SPEAR T-cells". Annals of Oncology. 29: viii412. doi:10.1093/annonc/mdy288.029.

Further reading

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