Microtubule-associated protein RP/EB family member 2 is a protein that in humans is encoded by the MAPRE2 gene.[5][6][7]

MAPRE2
Identifiers
AliasesMAPRE2, EB1, EB2, RP1, CSCSC2, microtubule associated protein RP/EB family member 2
External IDsOMIM: 605789; MGI: 106271; HomoloGene: 75027; GeneCards: MAPRE2; OMA:MAPRE2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001143826
NM_001143827
NM_001256420
NM_014268

NM_001162941
NM_001162942
NM_153058

RefSeq (protein)

NP_001137298
NP_001137299
NP_001243349
NP_055083

NP_001156413
NP_001156414
NP_694698

Location (UCSC)Chr 18: 34.98 – 35.14 MbChr 18: 23.89 – 24.03 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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The protein encoded by this gene shares significant homology to the adenomatous polyposis coli (APC) protein-binding EB1 gene family. The function of this protein is unknown; however, its homology suggests involvement in tumorigenesis of colorectal cancers and proliferative control of normal cells. This gene may belong to the intermediate/early gene family, involved in the signal transduction cascade downstream of the TCR.[7]

Interactions

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MAPRE2 has been shown to interact with APC.[8][9]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000166974Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024277Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Renner C, Pfitzenmeier JP, Gerlach K, Held G, Ohnesorge S, Sahin U, Bauer S, Pfreundschuh M (Aug 1997). "RP1, a new member of the adenomatous polyposis coli-binding EB1-like gene family, is differentially expressed in activated T cells". J Immunol. 159 (3): 1276–83. doi:10.4049/jimmunol.159.3.1276. PMID 9233623. S2CID 23797920.
  6. ^ Tirnauer JS, Canman JC, Salmon ED, Mitchison TJ (Dec 2002). "EB1 targets to kinetochores with attached, polymerizing microtubules". Mol Biol Cell. 13 (12): 4308–16. doi:10.1091/mbc.E02-04-0236. PMC 138635. PMID 12475954.
  7. ^ a b "Entrez Gene: MAPRE2 microtubule-associated protein, RP/EB family, member 2".
  8. ^ Su LK, Burrell M, Hill DE, Gyuris J, Brent R, Wiltshire R, Trent J, Vogelstein B, Kinzler KW (Jul 1995). "APC binds to the novel protein EB1". Cancer Res. 55 (14): 2972–7. PMID 7606712.
  9. ^ Nakamura M, Zhou XZ, Lu KP (Jul 2001). "Critical role for the EB1 and APC interaction in the regulation of microtubule polymerization". Curr. Biol. 11 (13): 1062–7. Bibcode:2001CBio...11.1062N. doi:10.1016/S0960-9822(01)00297-4. PMID 11470413. S2CID 14122895.

Further reading

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