E3 ubiquitin-protein ligase MARCH2 is an enzyme that in humans is encoded by the MARCH2gene.[5][6][7] It is a member of the MARCH family of E3 ligases, and plays an important role in the turnover of membrane proteins.[8] MARCH2 has been shown to negatively regulate NF-κB essential modulator function upon viral and bacterial infections.[9]
Like the other MARCH and septin genes, care must be exercised when analyzing genetic data containing the MARCH2 gene in Microsoft Excel.[10] This is due to Excel's autocorrect feature treating the MARCH gene as a date and converting it to a standard date format. The original text cannot be recovered as a result of the conversion. A 2016 study found up to 19.6% of all papers in selected journals to be affected by the gene name error.[11] The issue can be prevented by using an alias name such as MARCHF2, prepending with an apostrophe ('), or preformatting the cell as text.
^Zhang Y, Lu J, Liu X (May 2018). "MARCH2 is upregulated in HIV-1 infection and inhibits HIV-1 production through envelope protein translocation or degradation". Virology. 518: 293–300. doi:10.1016/j.virol.2018.02.003. PMID29573664.
