MB21D1

Cyclic GMP-AMP synthase is a protein that in humans is encoded by the CGAS gene. It's an enzyme, a nucleotidyltransferase, a cyclic GMP-AMP synthase.

CGAS
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4LEW, 4KM5, 4O67, 4MKP, 4LEV, 4O68, 4O69
Identifiers
Aliases	CGAS, C6orf150, cGAS, h-cGAS, Mab-21 domain containing 1, MB21D1, cyclic GMP-AMP synthase, Cyclic GMP-AMP synthase
External IDs	OMIM: 613973; MGI: 2442261; HomoloGene: 51384; GeneCards: CGAS; OMA:CGAS - orthologs
Gene location (Human) Chr. Chromosome 6 (human) Band 6q13 Start 73,413,515 bp End 73,452,297 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9|9 E1 Start 78,337,808 bp End 78,350,519 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pancreatic ductal cell buccal mucosa cell endothelial cell monocyte bone marrow cells granulocyte blood lymph node external globus pallidus cardia Top expressed in secondary oocyte primary oocyte zygote spermatocyte Paneth cell vas deferens condyle fossa conjunctival fornix bone marrow More reference expression data BioGPS n/a
Gene ontology Molecular function nucleotidyltransferase activity nucleotide binding metal ion binding GTP binding transferase activity ATP binding DNA binding 2',3'-cyclic GMP-AMP synthase activity double-stranded DNA binding chromatin binding protein binding Cellular component cytoplasm cytosol Biological process immune system process cyclic nucleotide biosynthetic process cellular response to exogenous dsRNA innate immune response activation of innate immune response defense response to virus positive regulation of defense response to virus by host cellular response to DNA damage stimulus positive regulation of type I interferon production paracrine signaling positive regulation of cellular senescence positive regulation of cGMP-mediated signaling positive regulation of cAMP-mediated signaling regulation of immunoglobulin production determination of adult lifespan regulation of type I interferon production regulation of immune response regulation of T cell activation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 115004 214763 Ensembl ENSG00000164430 ENSMUSG00000032344 UniProt Q8N884 Q8C6L5 RefSeq (mRNA) NM_138441 NM_173386 RefSeq (protein) NP_612450 NP_775562 Location (UCSC) Chr 6: 73.41 – 73.45 Mb Chr 9: 78.34 – 78.35 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human Cyclic GMP-AMP synthase (MB21D1)