MCC (gene)

Colorectal mutant cancer protein is a protein that in humans is encoded by the MCC gene.

MCC
Identifiers
Aliases	MCC, MCC1, mutated in colorectal cancers, WNT signaling pathway regulator, MCC regulator of WNT signaling pathway
External IDs	OMIM: 159350; MGI: 96930; HomoloGene: 20539; GeneCards: MCC; OMA:MCC - orthologs
Gene location (Human) Chr. Chromosome 5 (human) Band 5q22.2 Start 113,022,099 bp End 113,488,823 bp
Gene location (Mouse) Chr. Chromosome 18 (mouse) Band 18 B3|18 23.74 cM Start 44,558,127 bp End 44,945,249 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gingival epithelium sural nerve skin of hip left ovary germinal epithelium skin of thigh retinal pigment epithelium endothelial cell seminal vesicula pars reticulata Top expressed in zygote otolith organ utricle lobe of cerebellum cerebellar vermis secondary oocyte gastrula ventral tegmental area iris parotid gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding signaling receptor activity Cellular component cytoplasm plasma membrane cell projection membrane nucleus lamellipodium nucleoplasm cytosol Biological process establishment of protein localization negative regulation of epithelial cell proliferation negative regulation of epithelial cell migration Wnt signaling pathway negative regulation of canonical Wnt signaling pathway signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4163 328949 Ensembl ENSG00000171444 ENSMUSG00000071856 UniProt P23508 n/a RefSeq (mRNA) NM_001085377 NM_002387 NM_001033406 NM_001085373 NM_001085374 RefSeq (protein) NP_001078846 NP_002378 n/a Location (UCSC) Chr 5: 113.02 – 113.49 Mb Chr 18: 44.56 – 44.95 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

This gene is a candidate colorectal tumor suppressor gene that is thought to negatively regulate cell cycle progression. The orthologous gene in the mouse expresses a phosphoprotein associated with the plasma membrane and membrane organelles, and overexpression of the mouse protein inhibits entry into S phase. Multiple transcript variants encoding different isoforms have been found for this gene.

Further reading

• Lindgren V, Bryke CR, Ozcelik T, et al. (1992). "Phenotypic, cytogenetic, and molecular studies of three patients with constitutional deletions of chromosome 5 in the region of the gene for familial adenomatous polyposis". Am. J. Hum. Genet. 50 (5): 988–97. PMC 1682619. PMID 1315124.
• Nishisho I, Nakamura Y, Miyoshi Y, et al. (1991). "Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients". Science. 253 (5020): 665–9. Bibcode:1991Sci...253..665N. doi:10.1126/science.1651563. PMID 1651563.
• Hoshino Y, Horikawa I, Oshimura M, Yuasa Y (1991). "Normal human chromosome 5, on which a familial adenomatous polyposis gene is located, has tumor suppressive activity". Biochem. Biophys. Res. Commun. 174 (1): 298–304. doi:10.1016/0006-291X(91)90520-H. PMID 1846539.
• Curtis LJ, Bubb VJ, Gledhill S, et al. (1994). "Loss of heterozygosity of MCC is not associated with mutation of the retained allele in sporadic colorectal cancer". Hum. Mol. Genet. 3 (3): 443–6. doi:10.1093/hmg/3.3.443. PMID 8012355.
• Matsumine A, Senda T, Baeg GH, et al. (1996). "MCC, a cytoplasmic protein that blocks cell cycle progression from the G0/G1 to S phase". J. Biol. Chem. 271 (17): 10341–6. doi:10.1074/jbc.271.17.10341. PMID 8626604.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.