MDGA2 (MAM domain containing glycosylphosphatidylinositol anchor 2) is a human gene. It has previously been called MAMDC1.[1] MDGA2 is located on chromosome 14.
| MAM domain containing glycosylphosphatidylinositol anchor 2 | |
|---|---|
| Identifiers | |
| Symbol | MDGA2 |
| Alt. symbols | MAMDC1 |
| NCBI gene | 161357 |
| HGNC | 19835 |
| OMIM | 611128 |
| RefSeq | NM_182830 |
| Other data | |
| Locus | Chr. 14 q21.2 |
The gene has a homologue in rat and mouse, Mdga2,[2] and investigations in rats have found that the gene is expressed in the central and peripheral nervous system in a subpopulation of neurons, e.g., in the basilar pons and cerebral cortex.[3]
There are several variants in the human gene,[4] and a genome-wide association study has pointed to that single-nucleotide polymorphisms in MDGA2 is associated with neuroticism.[5] However, a more recent study has failed to replicate that finding.[6]
References
edit- ^ "MDGA2 Gene — GeneCards". Weizmann Institute of Science. 2008-09-08.
- ^ "Rat Genome Database: Mdga2 ( Rattus norvegicus )". Medical College of Wisconsin. Retrieved 2008-11-14.
- ^ Litwack ED, Babey R, Buser R, Gesemann M, O'Leary DD (February 2004). "Identification and characterization of two novel brain-derived immunoglobulin superfamily members with a unique structural organization". Molecular and Cellular Neuroscience. 25 (2): 263–264. doi:10.1016/j.mcn.2003.10.016. PMID 15019943. S2CID 25186151.
- ^ "SNP linked to Gene MDGA2". NCBI.
- ^ van den Oord EJ, Kuo PH, Hartmann AM, Webb BT, Möller HJ, Hettema JM, Giegling I, Bukszár J, Rujescu D (September 2008). "18762592". Archives of General Psychiatry. 65 (9): 1062–1071. doi:10.1001/archpsyc.65.9.1062. PMID 18762592.
- ^ Hettema, John M.; Oord, Edwin J.C.G. van den; An, Seon-Sook; Kendler, Kenneth S.; Chen, Xiangning (2009). "Follow-up association study of novel neuroticism gene MAMDC1". Psychiatric Genetics. 19 (4): 213–214. doi:10.1097/ypg.0b013e32832cec22. PMC 2844892. PMID 19440164.