MGUS polyneuropathy or polyneuropathy associated with an M component is a rare neurological disease characterized by inflammation of the peripheral nervous system and monoclonal gammopathy of undetermined significance (MGUS). It was first described in the 1960s. The main symptoms are progressive muscle weakness that is symmetrical and bilateral, ataxia, numbness and arm tremor. Treatments include intravenous immunoglobulin, which is a short-term treatment, immunosuppressants, though they have not been shown to be effective, autologous stem cell transplantation, and rituximab.[1][2][3]
References
edit- ^ "Polyneuropathy associated with an M component". The Swedish Information Centre for Rare Diseases. 2013-12-30. Archived from the original on 2019-02-07.
- ^ Gorson, Kenneth C. (1999). "Clinical features, evaluation, and treatment of patients with polyneuropathy associated with monoclonal gammopathy of undetermined significance (MGUS)". Journal of Clinical Apheresis. 14 (3): 149–153. doi:10.1002/(SICI)1098-1101(1999)14:3<149::AID-JCA8>3.0.CO;2-9. ISSN 0733-2459. PMID 10540371. Retrieved 12 March 2024.
- ^ Ramchandren, Sindhu; Lewis, Richard A. (February 2012). "An Update on Monoclonal Gammopathy and Neuropathy". Current Neurology and Neuroscience Reports. 12 (1): 102–110. doi:10.1007/s11910-011-0237-4. PMID 22090258.To be clear neuropathy is an umbrella term where poly neuropathy falls under
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