MIR200C

MicroRNA 200c is a microRNA that in humans is encoded by the MIR200C gene.

MIR200C
Identifiers
Aliases	MIR200C, MIRN200C, mir-200c, microRNA 200c
External IDs	OMIM: 612092; GeneCards: MIR200C; OMA:MIR200C - orthologs
Gene location (Human) Chr. Chromosome 12 (human) Band 12p13.31 Start 6,963,699 bp End 6,963,766 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in epididymis placenta glomerulus adrenal gland spleen fundus olfactory zone of nasal mucosa monocyte body of pancreas islet of Langerhans n/a More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 406985 n/a Ensembl ENSG00000207713 n/a UniProt n a n/a RefSeq (mRNA) n/a n/a RefSeq (protein) n/a n/a Location (UCSC) Chr 12: 6.96 – 6.96 Mb n/a PubMed search n/a
Wikidata
View/Edit Human

Function

MicroRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].

Further reading

• Hurteau GJ, Carlson JA, Spivack SD, Brock GJ (September 2007). "Overexpression of the microRNA hsa-miR-200c leads to reduced expression of transcription factor 8 and increased expression of E-cadherin". Cancer Res. 67 (17): 7972–6. doi:10.1158/0008-5472.CAN-07-1058. PMID 17804704.
• Hurteau GJ, Carlson JA, Roos E, Brock GJ (July 2009). "Stable expression of miR-200c alone is sufficient to regulate TCF8 (ZEB1) and restore E-cadherin expression". Cell Cycle. 8 (13): 2064–9. doi:10.4161/cc.8.13.8883. PMID 19502803.
• Shimono Y, Zabala M, Cho RW, Lobo N, Dalerba P, Qian D, Diehn M, Liu H, Panula SP, Chiao E, Dirbas FM, Somlo G, Pera RA, Lao K, Clarke MF (August 2009). "Downregulation of miRNA-200c links breast cancer stem cells with normal stem cells". Cell. 138 (3): 592–603. doi:10.1016/j.cell.2009.07.011. PMC 2731699. PMID 19665978.
• Sossey-Alaoui K, Bialkowska K, Plow EF (November 2009). "The miR200 family of microRNAs regulates WAVE3-dependent cancer cell invasion". J. Biol. Chem. 284 (48): 33019–29. doi:10.1074/jbc.M109.034553. PMC 2785142. PMID 19801681.
• Vrba L, Jensen TJ, Garbe JC, Heimark RL, Cress AE, Dickinson S, Stampfer MR, Futscher BW (January 2010). "Role for DNA methylation in the regulation of miR-200c and miR-141 expression in normal and cancer cells". PLOS ONE. 5 (1): e8697. Bibcode:2010PLoSO...5.8697V. doi:10.1371/journal.pone.0008697. PMC 2805718. PMID 20084174.
• Uhlmann S, Zhang JD, Schwäger A, Mannsperger H, Riazalhosseini Y, Burmester S, Ward A, Korf U, Wiemann S, Sahin O (July 2010). "miR-200bc/429 cluster targets PLCgamma1 and differentially regulates proliferation and EGF-driven invasion than miR-200a/141 in breast cancer". Oncogene. 29 (30): 4297–306. doi:10.1038/onc.2010.201. PMID 20514023. S2CID 41341426.
• Schickel R, Park SM, Murmann AE, Peter ME (June 2010). "miR-200c regulates induction of apoptosis through CD95 by targeting FAP-1". Mol. Cell. 38 (6): 908–15. doi:10.1016/j.molcel.2010.05.018. PMC 2904349. PMID 20620960.
• Ceppi P, Mudduluru G, Kumarswamy R, Rapa I, Scagliotti GV, Papotti M, Allgayer H (September 2010). "Loss of miR-200c expression induces an aggressive, invasive, and chemoresistant phenotype in non-small cell lung cancer". Mol. Cancer Res. 8 (9): 1207–16. doi:10.1158/1541-7786.MCR-10-0052. PMID 20696752.
• Leskelä S, Leandro-García LJ, Mendiola M, Barriuso J, Inglada-Pérez L, Muñoz I, Martínez-Delgado B, Redondo A, de Santiago J, Robledo M, Hardisson D, Rodríguez-Antona C (February 2011). "The miR-200 family controls beta-tubulin III expression and is associated with paclitaxel-based treatment response and progression-free survival in ovarian cancer patients". Endocr. Relat. Cancer. 18 (1): 85–95. doi:10.1677/ERC-10-0148. PMID 21051560.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.