MIR361

MicroRNA 361 is a micro RNA that in humans is encoded by the MIR361 gene.

MIR361
Identifiers
Aliases	MIR361, MIRN361, hsa-mir-361, mir-361, microRNA 361
External IDs	GeneCards: MIR361; OMA:MIR361 - orthologs
Gene location (Human) Chr. X chromosome (human) Band Xq21.2 Start 85,903,636 bp End 85,903,707 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in blood ascending aorta lung kidney stomach tibial arteries body of uterus human kidney fundus left ventricle n/a More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 494323 n/a Ensembl ENSG00000199051 n/a UniProt n a n/a RefSeq (mRNA) n/a n/a RefSeq (protein) n/a n/a Location (UCSC) Chr X: 85.9 – 85.9 Mb n/a PubMed search n/a
Wikidata
View/Edit Human

Function

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.