Histone H4 transcription factor is a protein that in humans is encoded by the HINFP gene.[4][5]

HINFP
Identifiers
AliasesHINFP, HiNF-P, MIZF, ZNF743, histone H4 transcription factor
External IDsOMIM: 607099; MGI: 2429620; HomoloGene: 9174; GeneCards: HINFP; OMA:HINFP - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001243259
NM_015517
NM_198971

NM_172162

RefSeq (protein)

NP_751894
NP_001391993
NP_001391994
NP_001391995

Location (UCSC)n/aChr 9: 44.2 – 44.22 Mb
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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HINFP is a protein that binds to a highly conserved DNA motif found in most histone H4 genes. HINFP activates H4 gene expression through interactions with the CDK2 substrate NPAT which is localized in Histone Locus Bodies. HINFP was independently described as a protein called "MBD2 interacting zinc finger protein" (MIZF). MIZF was reported to interact with methyl-CpG-binding protein-2 (MBD2; MIM 603547), a component of the MeCP1 histone deacetylase (HDAC) complex. MIZF is thought to play a role in DNA methylation and transcription repression.[supplied by OMIM][5]

Interactions

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One key partner protein of HINFP is NPAT, a CDK2 substrate that localizes to Histone Locus Bodies. MIZF has been reported to interact with Methyl-CpG-binding domain protein 2[4] and DHX9.[6]

References

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  1. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032119Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ a b Sekimata M, Takahashi A, Murakami-Sekimata A, Homma Y (November 2001). "Involvement of a novel zinc finger protein, MIZF, in transcriptional repression by interacting with a methyl-CpG-binding protein, MBD2". J. Biol. Chem. 276 (46): 42632–8. doi:10.1074/jbc.M107048200. PMID 11553631.
  5. ^ a b "Entrez Gene: MIZF MBD2-interacting zinc finger".
  6. ^ Fujita H, Fujii R, Aratani S, Amano T, Fukamizu A, Nakajima T (April 2003). "Antithetic effects of MBD2a on gene regulation". Mol. Cell. Biol. 23 (8): 2645–57. doi:10.1128/MCB.23.8.2645-2657.2003. PMC 152551. PMID 12665568.

Further reading

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