MMS22L

Methyl methanesulfonate-sensitivity protein 22-like also known as MMS22-like, DNA repair protein is a protein that in humans is encoded by the MMS22L gene.

MMS22L
Identifiers
Aliases	MMS22L, C6orf167, dJ39B17.2, MMS22 like, DNA repair protein
External IDs	OMIM: 615614; MGI: 2684980; HomoloGene: 18874; GeneCards: MMS22L; OMA:MMS22L - orthologs
Gene location (Human) Chr. Chromosome 6 (human) Band 6q16.1 Start 97,142,161 bp End 97,283,217 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4|4 A3 Start 24,496,451 bp End 24,602,950 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle ventricular zone ganglionic eminence bone marrow bone marrow cells gonad corpus callosum stromal cell of endometrium tonsil Achilles tendon Top expressed in ventricular zone tail of embryo medial ganglionic eminence epiblast secondary oocyte zygote genital tubercle primary oocyte endocardial cushion abdominal wall More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding Cellular component nuclear replication fork MCM complex nucleus FACT complex nucleoplasm cytosol Biological process double-strand break repair via homologous recombination DNA repair replication fork processing cellular response to DNA damage stimulus Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 253714 212377 Ensembl ENSG00000146263 ENSMUSG00000045751 UniProt Q6ZRQ5 B1AUR6 RefSeq (mRNA) NM_198468 NM_001350599 NM_001350600 NM_199467 RefSeq (protein) NP_940870 NP_001337528 NP_001337529 NP_955761 Location (UCSC) Chr 6: 97.14 – 97.28 Mb Chr 4: 24.5 – 24.6 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Further reading

• Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (Sep 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
• Duro E, Lundin C, Ask K, Sanchez-Pulido L, MacArtney TJ, Toth R, Ponting CP, Groth A, Helleday T, Rouse J (Nov 2010). "Identification of the MMS22L-TONSL complex that promotes homologous recombination". Molecular Cell. 40 (4): 632–44. doi:10.1016/j.molcel.2010.10.023. PMID 21055984.
• O'Connell BC, Adamson B, Lydeard JR, Sowa ME, Ciccia A, Bredemeyer AL, Schlabach M, Gygi SP, Elledge SJ, Harper JW (Nov 2010). "A genome-wide camptothecin sensitivity screen identifies a mammalian MMS22L-NFKBIL2 complex required for genomic stability". Molecular Cell. 40 (4): 645–57. doi:10.1016/j.molcel.2010.10.022. PMC 3006237. PMID 21055985.
• O'Donnell L, Panier S, Wildenhain J, Tkach JM, Al-Hakim A, Landry MC, Escribano-Diaz C, Szilard RK, Young JT, Munro M, Canny MD, Kolas NK, Zhang W, Harding SM, Ylanko J, Mendez M, Mullin M, Sun T, Habermann B, Datti A, Bristow RG, Gingras AC, Tyers MD, Brown GW, Durocher D (Nov 2010). "The MMS22L-TONSL complex mediates recovery from replication stress and homologous recombination". Molecular Cell. 40 (4): 619–31. doi:10.1016/j.molcel.2010.10.024. PMC 3031522. PMID 21055983.
• Piwko W, Olma MH, Held M, Bianco JN, Pedrioli PG, Hofmann K, Pasero P, Gerlich DW, Peter M (Dec 2010). "RNAi-based screening identifies the Mms22L-Nfkbil2 complex as a novel regulator of DNA replication in human cells". The EMBO Journal. 29 (24): 4210–22. doi:10.1038/emboj.2010.304. PMC 3018799. PMID 21113133.
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.