In enzymology, a mRNA (2'-O-methyladenosine-N6-)-methyltransferase (EC 2.1.1.62) is an enzyme that catalyzes the chemical reaction
| mRNA (2'-O-methyladenosine-N6-)-methyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.1.1.62 | ||||||||
| CAS no. | 68009-87-0 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
- S-adenosyl-L-methionine + m7G(5')pppAm S-adenosyl-L-homocysteine + m7G(5')pppm6Am (mRNA containing an N6,2'-O-dimethyladenosine cap)
Thus, the two substrates of this enzyme are S-adenosyl methionine and m7G(5')pppAm, whereas its two products are S-adenosylhomocysteine and m7G(5')pppm6Am (mRNA containing an N6,2'-O-dimethyladenosine cap).
This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:mRNA (2'-O-methyladenosine-N6-)-methyltransferase. Other names in common use include messenger ribonucleate 2'-O-methyladenosine NG-methyltransferase, S-adenosyl-L-methionine:mRNA, and (2'-O-methyladenosine-6-N-)-methyltransferase.
References
edit- Keith JM, Ensinger MJ, Mose B (1978). "HeLa cell RNA (2'-O-methyladenosine-N6-)-methyltransferase specific for the capped 5'-end of messenger RNA". J. Biol. Chem. 253 (14): 5033–9. PMID 670176.
