MRPS2

MRPS2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3J9M
Identifiers
Aliases	MRPS2, MRP-S2, S2mt, CGI-91, mitochondrial ribosomal protein S2, COXPD36
External IDs	OMIM: 611971; MGI: 2153089; HomoloGene: 99837; GeneCards: MRPS2; OMA:MRPS2 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	135,505,141 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	28,361,190 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; right adrenal gland; ; right adrenal cortex; ; mucosa of transverse colon; ; right lobe of liver; ; left adrenal gland; ; right uterine tube; ; gastrocnemius muscle; ; left adrenal cortex; ; left ventricle;
	Top expressed in
	primitive streak; ; abdominal wall; ; mandibular prominence; ; maxillary prominence; ; tail of embryo; ; endocardial cushion; ; epiblast; ; migratory enteric neural crest cell; ; genital tubercle; ; proximal tubule;
	More reference expression data
	n/a
Gene ontology
Molecular function	structural constituent of ribosome;
Cellular component	small ribosomal subunit; ribosome; intracellular anatomical structure; mitochondrion; mitochondrial inner membrane; mitochondrial small ribosomal subunit;
Biological process	protein biosynthesis; mitochondrial translation; mitochondrial translational elongation; mitochondrial translational termination; mitochondrial ribosome assembly;
	Sources:Amigo / QuickGO
Orthologs
	51116
	118451
	ENSG00000122140
	ENSMUSG00000035772
	Q9Y399
	Q924T2
	NM_016034; NM_001371401
	NM_001166031; NM_080452
	NP_057118; NP_001358330
	NP_001159503; NP_536700
	Wikidata
View/Edit Human	View/Edit Mouse

Mitochondrial ribosomal protein S2 (MRPS2), otherwise known as uS2m, is a protein that in humans is encoded by the MRPS2 gene. ^[5]

Function

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S2 family. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012].

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000122140 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000035772 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Mitochondrial ribosomal protein S2". Retrieved 2018-02-11.

External links

Overview of all the structural information available in the PDB for UniProt: Q9Y399 (Human 28S ribosomal protein S2, mitochondrial (MRPS2)) at the PDBe-KB.

This article on a gene on human chromosome 9 is a stub. You can help Wikipedia by expanding it.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000122140 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000035772 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Mitochondrial ribosomal protein S2". Retrieved 2018-02-11.

[5]

[1]

[2]

[3]

[4]

MRPS2

Contents

Function

See also

References

Further reading

External links