MRPS7

28S ribosomal protein S7, mitochondrial is a protein that in humans is encoded by the MRPS7 gene.

MRPS7
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3J9M
Identifiers
Aliases	MRPS7, MRP-S, MRP-S7, RP-S7, RPMS7, S7mt, bMRP27a, mitochondrial ribosomal protein S7, COXPD34
External IDs	OMIM: 611974; MGI: 1354367; HomoloGene: 9321; GeneCards: MRPS7; OMA:MRPS7 - orthologs
Gene location (Human) Chr. Chromosome 17 (human) Band 17q25.1 Start 75,261,674 bp End 75,266,376 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11|11 E2 Start 115,494,751 bp End 115,498,862 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastrocnemius muscle apex of heart left ventricle right auricle mucosa of transverse colon muscle of thigh right adrenal gland right adrenal cortex left adrenal gland left adrenal cortex Top expressed in right kidney right ventricle interventricular septum proximal tubule cardiac muscle tissue of left ventricle plantaris muscle epiblast muscle of thigh left lobe of liver masseter muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function RNA binding mRNA binding structural constituent of ribosome rRNA binding Cellular component mitochondrial inner membrane ribosome mitochondrion mitochondrial small ribosomal subunit Biological process mitochondrial translational elongation mitochondrial translational termination mitochondrial translation ribosomal small subunit assembly protein biosynthesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51081 50529 Ensembl ENSG00000125445 ENSMUSG00000046756 UniProt Q9Y2R9 Q80X85 RefSeq (mRNA) NM_015971 NM_025305 RefSeq (protein) NP_057055 NP_079581 Location (UCSC) Chr 17: 75.26 – 75.27 Mb Chr 11: 115.49 – 115.5 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. In the prokaryotic ribosome, the comparable protein is thought to play an essential role in organizing the 3' domain of the 16S rRNA in the vicinity of the P- and A-sites. Pseudogenes corresponding to this gene are found on chromosomes 8p and 12p.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Cavdar Koc E, Blackburn K, Burkhart W, Spremulli LL (2000). "Identification of a mammalian mitochondrial homolog of ribosomal protein S7". Biochem. Biophys. Res. Commun. 266 (1): 141–146. doi:10.1006/bbrc.1999.1785. PMID 10581179.
• Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–1560. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
• Cavdar Koc E, Burkhart W, Blackburn K, et al. (2001). "The small subunit of the mammalian mitochondrial ribosome. Identification of the full complement of ribosomal proteins present". J. Biol. Chem. 276 (22): 19363–19374. doi:10.1074/jbc.M100727200. PMID 11279123.
• Suzuki T, Terasaki M, Takemoto-Hori C, et al. (2001). "Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28 S small subunit". J. Biol. Chem. 276 (35): 33181–33195. doi:10.1074/jbc.M103236200. PMID 11402041.
• Kenmochi N, Suzuki T, Uechi T, et al. (2001). "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders". Genomics. 77 (1–2): 65–70. doi:10.1006/geno.2001.6622. PMID 11543634.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Zhang Z, Gerstein M (2003). "Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome". Genomics. 81 (5): 468–480. doi:10.1016/S0888-7543(03)00004-1. PMID 12706105.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.