MS 22, MS-22 or MS22 may refer to:

  • Mississippi Highway 22 (MS 22), a state highway in central Mississippi, United States
  • Soyuz MS-22, a Russian Soyuz crewed spaceflight to the ISS
  • Progress MS-22, a Russian Progress cargo spaceflight to the ISS
  • Minuscule 22 (MS22), Codex Colbertinus 2467, ε 288), a Greek minuscule manuscript of the New Testament

See also

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