MT1X

Metallothionein 1X, also known as MT1X, is a protein which in humans is encoded by the gene.

MT1X
Identifiers
Aliases	MT1X, MT-1l, MT1, metallothionein 1X
External IDs	OMIM: 156359; HomoloGene: 130542; GeneCards: MT1X; OMA:MT1X - orthologs
Gene location (Human) Chr. Chromosome 16 (human) Band 16q13 Start 56,682,470 bp End 56,684,196 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pericardium right lobe of liver gastrocnemius muscle right lobe of thyroid gland left lobe of thyroid gland skin of abdomen muscle of thigh skin of leg tibialis anterior muscle external globus pallidus n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding metal ion binding zinc ion binding copper ion binding Cellular component cytoplasm perinuclear region of cytoplasm nucleus lysosome cytosol Biological process response to metal ion cellular response to erythropoietin negative regulation of growth cellular response to cadmium ion cellular response to zinc ion cellular metal ion homeostasis cellular zinc ion homeostasis nitric oxide mediated signal transduction detoxification of copper ion negative regulation of neuron apoptotic process cellular response to chromate cellular response to copper ion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4501 n/a Ensembl ENSG00000187193 n/a UniProt P80297 n/a RefSeq (mRNA) NM_005952 n/a RefSeq (protein) NP_005943 n/a Location (UCSC) Chr 16: 56.68 – 56.68 Mb n/a PubMed search n/a
Wikidata
View/Edit Human

See also

• Metallothionein

Further reading

• West AK, Stallings R, Hildebrand CE, et al. (1991). "Human metallothionein genes: structure of the functional locus at 16q13". Genomics. 8 (3): 513–8. doi:10.1016/0888-7543(90)90038-V. PMID 2286373.
• Stennard FA, Holloway AF, Hamilton J, West AK (1994). "Characterisation of six additional human metallothionein genes". Biochim. Biophys. Acta. 1218 (3): 357–65. doi:10.1016/0167-4781(94)90189-9. PMID 8049263.
• Pauwels M, van Weyenbergh J, Soumillion A, et al. (1994). "Induction by zinc of specific metallothionein isoforms in human monocytes". Eur. J. Biochem. 220 (1): 105–10. doi:10.1111/j.1432-1033.1994.tb18603.x. PMID 8119276.
• Mididoddi S, McGuirt JP, Sens MA, et al. (1996). "Isoform-specific expression of metallothionein mRNA in the developing and adult human kidney". Toxicol. Lett. 85 (1): 17–27. doi:10.1016/0378-4274(96)03632-6. PMID 8619255.
• Holloway AF, Stennard FA, West AK (1997). "Human metallothionein gene MT1L mRNA is present in several human tissues but is unlikely to produce a metallothionein protein". FEBS Lett. 404 (1): 41–4. doi:10.1016/S0014-5793(97)00082-3. PMID 9074634. S2CID 46527743.
• Garrett SH, Somji S, Todd JH, et al. (1999). "Differential expression of human metallothionein isoform I mRNA in human proximal tubule cells exposed to metals". Environ. Health Perspect. 106 (12): 825–32. doi:10.2307/3434126. JSTOR 3434126. PMC 1533231. PMID 9831543.
• Hellemans G, Soumillion A, Proost P, et al. (2000). "Metallothioneins in human kidneys and associated tumors". Nephron. 83 (4): 331–40. doi:10.1159/000045425. PMID 10575295. S2CID 26103380.
• Garrett SH, Sens MA, Shukla D, et al. (2000). "Metallothionein isoform 1 and 2 gene expression in the human prostate: downregulation of MT-1X in advanced prostate cancer". Prostate. 43 (2): 125–35. doi:10.1002/(SICI)1097-0045(20000501)43:2<125::AID-PROS7>3.0.CO;2-S. PMID 10754528. S2CID 8768274.
• Vandeghinste N, Proost P, De Ley M (2000). "Metallothionein isoform gene expression in zinc-treated human peripheral blood lymphocytes". Cell. Mol. Biol. (Noisy-le-grand). 46 (2): 419–33. PMID 10774930.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Rahman MT, De Ley M (2001). "Metallothionein isogene transcription in red blood cell precursors from human cord blood". Eur. J. Biochem. 268 (3): 849–56. doi:10.1046/j.1432-1327.2001.01947.x. PMID 11168427.
• Garrett SH, Belcastro M, Sens MA, et al. (2001). "Acute exposure to arsenite induces metallothionein isoform-specific gene expression in human proximal tubule cells". J. Toxicol. Environ. Health A. 64 (4): 343–55. Bibcode:2001JTEHA..64..343G. doi:10.1080/152873901316981321. PMID 11693492. S2CID 43143430.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Izmailova E, Bertley FM, Huang Q, et al. (2003). "HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages". Nat. Med. 9 (2): 191–7. doi:10.1038/nm822. PMID 12539042. S2CID 26145639.
• Anderson NL, Polanski M, Pieper R, et al. (2004). "The human plasma proteome: a nonredundant list developed by combination of four separate sources". Mol. Cell. Proteomics. 3 (4): 311–26. doi:10.1074/mcp.M300127-MCP200. PMID 14718574.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.