Max-interacting transcriptional repressor MAD4 is a protein that in humans is encoded by the MXD4 gene.[5][6]

MXD4
Identifiers
AliasesMXD4, MAD4, MST149, MSTP149, bHLHc12, MAX dimerization protein 4
External IDsMGI: 104991; HomoloGene: 4712; GeneCards: MXD4; OMA:MXD4 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006454

NM_010753

RefSeq (protein)

NP_006445

n/a

Location (UCSC)Chr 4: 2.25 – 2.26 MbChr 5: 34.33 – 34.35 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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This gene is a member of the MAD gene family . The MAD genes encode basic helix-loop-helix-leucine zipper proteins that heterodimerize with MAX protein, forming a transcriptional repression complex. The MAD proteins compete for MAX binding with MYC, which heterodimerizes with MAX forming a transcriptional activation complex. Studies in rodents suggest that the MAD genes are tumor suppressors and contribute to the regulation of cell growth in differentiating tissues.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000123933Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037235Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Hurlin PJ, Quéva C, Koskinen PJ, Steingrímsson E, Ayer DE, Copeland NG, Jenkins NA, Eisenman RN (November 1995). "Mad3 and Mad4: novel Max-interacting transcriptional repressors that suppress c-myc dependent transformation and are expressed during neural and epidermal differentiation". The EMBO Journal. 14 (22): 5646–59. doi:10.1002/j.1460-2075.1995.tb00252.x. PMC 394680. PMID 8521822.
  6. ^ a b "Entrez Gene: MXD4 MAX dimerization protein 4".

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.