Myosin light polypeptide 6 is a protein that in humans is encoded by the MYL6 gene.[5][6][7][8]

MYL6
Identifiers
AliasesMYL6, ESMLC, LC17, LC17-GI, LC17-NM, LC17A, LC17B, MLC-3, MLC1SM, MLC3NM, MLC3SM, myosin light chain 6
External IDsOMIM: 609931; MGI: 109318; HomoloGene: 69080; GeneCards: MYL6; OMA:MYL6 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_079425
NM_021019
NM_079423

NM_010860
NM_001317217
NM_001317218
NM_001317219
NM_001317220

RefSeq (protein)

NP_066299
NP_524147

NP_001304146
NP_001304147
NP_001304148
NP_001304149
NP_034990

Location (UCSC)Chr 12: 56.16 – 56.16 MbChr 10: 128.33 – 128.33 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Myosin is a hexameric ATPase cellular motor protein. It is composed of two heavy chains, two nonphosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. This gene encodes a myosin alkali light chain that is expressed in smooth muscle and non-muscle tissues. Genomic sequences representing several pseudogenes have been described and two transcript variants encoding different isoforms have been identified for this gene.[8]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000092841Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000090841Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Bora PS, Bora NS, Wu X, Kaplan HJ, Lange LG (Jun 1994). "Molecular cloning, sequencing, and characterization of smooth muscle myosin alkali light chain from human eye cDNA: homology with myocardial fatty acid ethyl ester synthase-III cDNA". Genomics. 19 (1): 186–8. doi:10.1006/geno.1994.1041. PMID 8188229.
  6. ^ Hailstones DL, Gunning PW (Mar 1990). "Characterization of human myosin light chains 1sa and 3nm: implications for isoform evolution and function". Mol Cell Biol. 10 (3): 1095–104. doi:10.1128/mcb.10.3.1095. PMC 360973. PMID 2304459.
  7. ^ Lenz S, Lohse P, Seidel U, Arnold HH (Jun 1989). "The alkali light chains of human smooth and nonmuscle myosins are encoded by a single gene. Tissue-specific expression by alternative splicing pathways". J Biol Chem. 264 (15): 9009–15. doi:10.1016/S0021-9258(18)81895-6. PMID 2722814.
  8. ^ a b "Entrez Gene: MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle".

Further reading

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