Mabus may refer to:
- An alleged predecessor to the third antichrist, or the antichrist itself, according to Nostradamus in popular culture
- Quatrain 2:62, work by Nostradamus
- Mabus Point, a cape on the Antarctic coast
- Ray Mabus, former U.S. Secretary of the Navy, former Governor of Mississippi, former U.S. Ambassador
- Brawlhalla player, two defense Ember enthusiast
- A musical work for large symphony orchestra by French contemporary composer Jean-Louis Agobet
- First single from 'Devilish' album by Brazilian death/thrash metal band Torture Squad