Mackworth may refer to:
- Mackworth, Amber Valley, a village and civil parish in Derbyshire, England
- Mackworth, Derby, a housing estate and ward in the city of Derby, Derbyshire, England
- Humphrey Mackworth (1657–1727)
- Humphrey Mackworth (born 1631)
This disambiguation page lists articles about distinct geographical locations with the same name.
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