Magnano is an Italian-language occupational surname, literally meaning locksmith. Notable people with the surname include:
- Greg Mangano (born 1989), American basketball player
- Joy Mangano (born 1956), American inventor of the Miracle Mop
- Rubén Magnano (born 1954), Argentine-Italian professional basketball coach
- Silvana Mangano (1930–1989), Italian actress
- Solange Magnano (1971–2009), Argentine model and beauty queen