Makemake is a large planetoid in the Kuiper belt.
Makemake may also refer to:
- Makemake (deity), the creator of humanity in the mythology of Easter Island
- a make-makefile tool in build automation
- "Make Make", a song by Mike Oldfield from Heaven's Open
- Make-Make, an album by Jabberwocky
- The Makemakes, an Austrian pop-rock band