Makena may refer to:
- Makena Onjerika, Kenyan writer and 2018 Caine Prize winner
- A brand name of the medication hydroxyprogesterone caproate
- Makena, Hawaii, a census-designated place in Maui County, Hawaii
- Makena State Park
- Makena Beach & Golf Resort, a resort in Maui
- Makena, one of the nine playable characters in the game Minecraft