In enzymology, a maleimide hydrolase (EC 3.5.2.16) is an enzyme that catalyzes the chemical reaction
maleimide hydrolase | |||||||||
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Identifiers | |||||||||
EC no. | 3.5.2.16 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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- maleimide + H2O maleamic acid
Thus, the two substrates of this enzyme are maleimide and H2O, whereas its product is maleamic acid.
This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in cyclic amides. The systematic name of this enzyme class is cyclic-imide amidohydrolase (decyclizing). Other names in common use include imidase, cyclic imide hydrolase, and cyclic-imide amidohydrolase (decyclicizing) [misprint].
References
edit- Ogawa J, Soong CL, Honda M, Shimizu S (1997). "Imidase, a dihydropyrimidinase-like enzyme involved in the metabolism of cyclic imides". Eur. J. Biochem. 243 (1–2): 322–7. doi:10.1111/j.1432-1033.1997.0322a.x. PMID 9030755.