Mammaglobin-A

Mammaglobin-A also known as secretoglobin family 2A member 2 is a protein that in humans is encoded by the SCGB2A2 gene.

SCGB2A2
Identifiers
Aliases	SCGB2A2, MGB1, UGB2, secretoglobin family 2A member 2, PSBP1
External IDs	OMIM: 605562; HomoloGene: 82995; GeneCards: SCGB2A2; OMA:SCGB2A2 - orthologs
Gene location (Human) Chr. Chromosome 11 (human) Band 11q12.3 Start 62,270,158 bp End 62,273,160 bp
Gene location (Mouse) Chr. Chromosome 19 (mouse) Band 19 A Start 9,847,562 bp End 9,852,808 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of thigh skin of arm skin of hip epithelium of lactiferous gland lactiferous duct testicle olfactory zone of nasal mucosa skin of abdomen minor salivary glands gonad Top expressed in embryo embryo genital tubercle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding molecular function Cellular component cellular component extracellular region extracellular space Biological process biological process androgen receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4250 102639117 Ensembl ENSG00000110484 ENSMUSG00000096872 UniProt Q13296 J3KMP9 RefSeq (mRNA) NM_002411 XM_006527538 RefSeq (protein) NP_002402 NP_001365339 Location (UCSC) Chr 11: 62.27 – 62.27 Mb Chr 19: 9.85 – 9.85 Mb PubMed search
Wikidata
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Function

SCGB2A2 is a member of the superfamily of secretoglobins, a group of small dimeric secreted and sometimes glycosylated proteins. Expressed mainly in mucosa, secretoglobins seem to be involved in cell signalling, immune response, and chemotaxis, and may also serve as transporters for steroid hormones in humans.

Clinical significance

SCGB2A2 expression is highly specific of mammary tissue, and is increasingly used for identification and detection of disseminated breast cancer cells.

Further reading

• Wilson PC, de Bouteiller O, Liu YJ, Potter K, Banchereau J, Capra JD, Pascual V (1998). "Somatic hypermutation introduces insertions and deletions into immunoglobulin V genes". J. Exp. Med. 187 (1): 59–70. doi:10.1084/jem.187.1.59. PMC 2199186. PMID 9419211.
• Fischer M, Küppers R (1998). "Human IgA- and IgM-secreting intestinal plasma cells carry heavily mutated VH region genes". Eur. J. Immunol. 28 (9): 2971–7. doi:10.1002/(SICI)1521-4141(199809)28:09<2971::AID-IMMU2971>3.0.CO;2-3. PMID 9754584. S2CID 26597499.
• Carter D, Douglass JF, Cornellison CD, Retter MW, Johnson JC, Bennington AA, Fleming TP, Reed SG, Houghton RL, Diamond DL, Vedvick TS (2002). "Purification and characterization of the mammaglobin/lipophilin B complex, a promising diagnostic marker for breast cancer". Biochemistry. 41 (21): 6714–22. doi:10.1021/bi0159884. PMID 12022875.
• Izmailova E, Bertley FM, Huang Q, Makori N, Miller CJ, Young RA, Aldovini A (2003). "HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages". Nat. Med. 9 (2): 191–7. doi:10.1038/nm822. PMID 12539042. S2CID 26145639.
• Cerveira N, Torres L, Rocha P, Bizarro S, Pereira D, Abreu J, Henrique R, Teixeira MR, Castedo S (2004). "Highly sensitive detection of the MGB1 transcript (mammaglobin) in the peripheral blood of breast cancer patients". Int. J. Cancer. 108 (4): 592–5. doi:10.1002/ijc.11609. PMID 14696125. S2CID 13567521.
• Ouellette RJ, Richard D, Maïcas E (2004). "RT-PCR for mammaglobin genes, MGB1 and MGB2, identifies breast cancer micrometastases in sentinel lymph nodes". Am. J. Clin. Pathol. 121 (5): 637–43. doi:10.1309/MMAC-TXT5-5L8Q-TKC1. PMID 15151203. S2CID 35965043.
• Ferrucci PF, Rabascio C, Mazzetta C, Cocorocchio E, Agazzi A, Vanazzi A, Cinieri S, Peccatori FA, Paolucci M, Bertolini F, Martinelli G (2005). "Mammaglobin expression in leukapheresis products is a predictive marker of poor prognosis in women with high-risk breast cancer". Clin. Cancer Res. 10 (18 Pt 1): 6039–46. doi:10.1158/1078-0432.CCR-03-0453. PMID 15447988. S2CID 28424184.
• O'Brien NA, O'Donovan N, Ryan B, Hill AD, McDermott E, O'Higgins N, Duffy MJ (2005). "Mammaglobin a in breast cancer: existence of multiple molecular forms". Int. J. Cancer. 114 (4): 623–7. doi:10.1002/ijc.20780. PMID 15609337. S2CID 23187797.
• Roncella S, Ferro P, Bacigalupo B, Pronzato P, Tognoni A, Falco E, Gianquinto D, Ansaldo V, Dessanti P, Fais F, Rosai J, Fedeli F (2005). "Human mammaglobin mRNA is a reliable molecular marker for detecting occult breast cancer cells in peripheral blood". J. Exp. Clin. Cancer Res. 24 (2): 265–71. PMID 16110760.
• Span PN, Sweep FC (2006). "Mammaglobin as molecular marker of breast cancer (micro)metastases". Clin. Cancer Res. 11 (19 Pt 1): 7043–7044. doi:10.1158/1078-0432.CCR-05-1378. PMID 16203799. S2CID 39344532.
• Roncella S, Ferro P, Bacigalupo B, Dessanti P, Giannico A, Gorji N, Moroni M, Tozzini S, Pensa F, Gianquinto D, Fais F, Pronzato P, Fedeli F (2006). "Relationship between human mammaglobin mRNA expression in breast cancer tissue and clinico-pathologic features of the tumors". J. Exp. Clin. Cancer Res. 25 (1): 65–72. PMID 16761620.
• Ntoulia M, Stathopoulou A, Ignatiadis M, Malamos N, Mavroudis D, Georgoulias V, Lianidou ES (2007). "Detection of Mammaglobin A-mRNA-positive circulating tumor cells in peripheral blood of patients with operable breast cancer with nested RT-PCR". Clin. Biochem. 39 (9): 879–87. doi:10.1016/j.clinbiochem.2006.06.009. PMID 16925986.
• Gimbergues P, Dauplat MM, Cayre A, Durando X, Le Bouedec G, Finat-Duclos F, Portefaix G, Kwiatkowski F, Dauplat J, Penault-Llorca F, Tchirkov A (2007). "Correlation between molecular metastases in sentinel lymph nodes of breast cancer patients and St Gallen risk category". Eur J Surg Oncol. 33 (1): 16–22. doi:10.1016/j.ejso.2006.09.013. PMID 17071045.
• Sasaki E, Tsunoda N, Hatanaka Y, Mori N, Iwata H, Yatabe Y (2007). "Breast-specific expression of MGB1/mammaglobin: an examination of 480 tumors from various organs and clinicopathological analysis of MGB1-positive breast cancers". Mod. Pathol. 20 (2): 208–14. doi:10.1038/modpathol.3800731. PMID 17192791.