Mammaglobin-B also known as secretoglobin family 2A member 1 is a protein that in humans is encoded by the SCGB2A1 gene .[ 5] [ 6]
SCGB2A1 and breast cancer
edit
SCGB2A1 expression is highly specific of mammary tissue, and has been used for identification and detection of disseminated breast cancer cells.[ 7]
^ a b c GRCh38: Ensembl release 89: ENSG00000124939 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000096872 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Becker RM, Darrow C, Zimonjic DB, Popescu NC, Watson MA, Fleming TP (Jan 1999). "Identification of mammaglobin B, a novel member of the uteroglobin gene family". Genomics . 54 (1): 70–8. doi :10.1006/geno.1998.5539 . PMID 9806831 . ^ "Entrez Gene: SCGB2A1 secretoglobin, family 2A, member 1" .^ Lacroix, M (2006). "Significance, detection and markers of disseminated breast cancer cells" . Endocrine-Related Cancer 13 (4). Bioscientifica : 1033–1067. doi :10.1677/ERC-06-0001 PMID 17158753 .
Molloy MP, Bolis S, Herbert BR, et al. (1998). "Establishment of the human reflex tear two-dimensional polyacrylamide gel electrophoresis reference map: new proteins of potential diagnostic value". Electrophoresis . 18 (15): 2811–5. doi :10.1002/elps.1150181516 . PMID 9504814 . S2CID 39202047 . Lehrer RI, Xu G, Abduragimov A, et al. (1998). "Lipophilin, a novel heterodimeric protein of human tears" . FEBS Lett . 432 (3): 163–7. Bibcode :1998FEBSL.432..163L . doi :10.1016/S0014-5793(98)00852-7 PMID 9720917 . S2CID 205880914 . Zhao C, Nguyen T, Yusifov T, et al. (1999). "Lipophilins: human peptides homologous to rat prostatein". Biochem. Biophys. Res. Commun . 256 (1): 147–55. doi :10.1006/bbrc.1999.0274 . PMID 10066439 . Evans V, Vockler C, Friedlander M, et al. (2001). "Lacryglobin in human tears, a potential marker for cancer". Clin. Experiment. Ophthalmol . 29 (3): 161–3. doi :10.1046/j.1442-9071.2001.00408.x . PMID 11446459 . S2CID 41723656 . Carter D, Douglass JF, Cornellison CD, et al. (2002). "Purification and characterization of the mammaglobin/lipophilin B complex, a promising diagnostic marker for breast cancer". Biochemistry . 41 (21): 6714–22. doi :10.1021/bi0159884 . PMID 12022875 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Izmailova E, Bertley FM, Huang Q, et al. (2003). "HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages". Nat. Med . 9 (2): 191–7. doi :10.1038/nm822 . PMID 12539042 . S2CID 26145639 . Sjödin A, Guo D, Sørhaug S, et al. (2003). "Dysregulated secretoglobin expression in human lung cancers". Lung Cancer . 41 (1): 49–56. doi :10.1016/S0169-5002(03)00126-0 . PMID 12826312 . Ouellette RJ, Richard D, Maïcas E (2004). "RT-PCR for mammaglobin genes, MGB1 and MGB2, identifies breast cancer micrometastases in sentinel lymph nodes" . Am. J. Clin. Pathol . 121 (5): 637–43. doi :10.1309/MMAC-TXT5-5L8Q-TKC1 PMID 15151203 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Xiao F, Mirwald A, Papaioannou M, et al. (2006). "Secretoglobin 2A1 is under selective androgen control mediated by a peculiar binding site for Sp family transcription factors" . Mol. Endocrinol . 19 (12): 2964–78. doi :10.1210/me.2004-0408 PMID 16020486 . Bernstein JL, Godbold JH, Raptis G, et al. (2005). "Identification of mammaglobin as a novel serum marker for breast cancer" . Clin. Cancer Res . 11 (18): 6528–35. doi :10.1158/1078-0432.CCR-05-0415 PMID 16166429 .
