The mammalian CPEB3 ribozyme is a self cleaving non-coding RNA located in the second intron of the CPEB3 gene which belongs to a family of genes regulating messenger RNA polyadenylation.[1] This ribozyme is highly conserved and found only in mammals.[1] The CPEB3 ribozyme is structurally and biochemically related to the human hepatitis delta virus ribozyme.[2] Other HDV-like ribozymes have been identified and confirmed to be active in vitro in a number of eukaryotes.[3]
| Mammalian CPEB3 ribozyme | |
|---|---|
 Predicted secondary structure and sequence conservation of CPEB3_ribozyme | |
| Identifiers | |
| Symbol | CPEB3_ribozyme |
| Rfam | RF00622 |
| Other data | |
| RNA type | Gene; ribozyme |
| Domain(s) | Eukaryota |
| SO | SO:0000374 |
| PDB structures | PDBe |
References
edit- ^ a b Salehi-Ashtiani K, Luptak A, Litovchick A, Szostak JW (2006). "A genomewide search for ribozymes reveals an HDV-like sequence in thehuman CPEB3 gene". Science. 313 (5794): 1788–1792. Bibcode:2006Sci...313.1788S. doi:10.1126/science.1129308. PMID 16990549. S2CID 43309772.
- ^ Chadalavada DM, Gratton EA, Bevilacqua PC (2010). "The Human HDV-like CPEB3 Ribozyme Is Intrinsically Fast-Reacting". Biochemistry. 49 (25): 5321–5330. doi:10.1021/bi100434c. PMC 2890282. PMID 20524672.
- ^ Webb, CH; Riccitelli, NJ; Ruminski, DJ; Lupták, A (Nov 13, 2009). "Widespread occurrence of self-cleaving ribozymes". Science. 326 (5955): 953. Bibcode:2009Sci...326..953W. doi:10.1126/science.1178084. PMC 3159031. PMID 19965505.
External links
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