Mangum is a surname. Notable people with the surname include:
- Crystal Mangum, American woman who perpetrated the 2006 Duke University lacrosse rape hoax and later murdered her partner
- Dusty Mangum, American football player
- Jake Mangum, American baseball player
- Jeff Mangum, American musician and songwriter
- John Mangum (disambiguation), several people
- Jonathan Mangum, American actor and comedian
- Kris Mangum, American football player
- Pete Mangum (1931–2000), American football player
- Tanner Mangum, American football player
- Willie Person Mangum, American politician