Mannose receptor C-type 1

Mannose receptor C-type 1 is a protein that in humans is encoded by the MRC1 gene. [5]

MRC1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMRC1, CD206, CLEC13D, CLEC13DL, MMR, MRC1L1, bA541I19.1, hMR, mannose receptor, C type 1, mannose receptor C-type 1
External IDsOMIM: 153618; MGI: 97142; HomoloGene: 37622; GeneCards: MRC1; OMA:MRC1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002438
NM_001009567

NM_008625

RefSeq (protein)

NP_002429

NP_032651

Location (UCSC)Chr 10: 17.81 – 17.91 MbChr 2: 14.23 – 14.34 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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The recognition of complex carbohydrate structures on glycoproteins is an important part of several biological processes, including cell-cell recognition, serum glycoprotein turnover, and neutralization of pathogens. The protein encoded by this gene is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. The protein has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment.

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000260314Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026712Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Mannose receptor C-type 1". Retrieved 2018-10-15.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.