Mannose receptor C-type 1

Mannose receptor C-type 1 is a protein that in humans is encoded by the MRC1 gene.

MRC1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1EGG, 1EGI
Identifiers
Aliases	MRC1, CD206, CLEC13D, CLEC13DL, MMR, MRC1L1, bA541I19.1, hMR, mannose receptor, C type 1, mannose receptor C-type 1
External IDs	OMIM: 153618; MGI: 97142; HomoloGene: 37622; GeneCards: MRC1; OMA:MRC1 - orthologs
Gene location (Human) Chr. Chromosome 10 (human) Band 10p12.33 Start 17,809,348 bp End 17,911,164 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2 A2|2 10.46 cM Start 14,234,203 bp End 14,336,868 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in lower lobe of lung visceral pleura secondary oocyte decidua pericardium superficial temporal artery synovial membrane synovial joint skin of hip right ventricle Top expressed in stroma of bone marrow vestibular sensory epithelium dermis umbilical cord carotid body tunica adventitia of aorta skin of external ear calvaria efferent ductule sciatic nerve More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding mannose binding transmembrane signaling receptor activity carbohydrate binding virus receptor activity Cellular component integral component of membrane cell surface endosome plasma membrane integral component of plasma membrane endosome membrane membrane Biological process cellular response to interferon-gamma cellular response to interleukin-4 viral entry into host cell viral process cellular response to lipopolysaccharide endocytosis receptor-mediated endocytosis signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4360 17533 Ensembl ENSG00000260314 ENSMUSG00000026712 UniProt P22897 Q61830 RefSeq (mRNA) NM_002438 NM_001009567 NM_008625 RefSeq (protein) NP_002429 NP_032651 Location (UCSC) Chr 10: 17.81 – 17.91 Mb Chr 2: 14.23 – 14.34 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

The recognition of complex carbohydrate structures on glycoproteins is an important part of several biological processes, including cell-cell recognition, serum glycoprotein turnover, and neutralization of pathogens. The protein encoded by this gene is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. The protein has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment.

Further reading

• DesJardin LE, Kaufman TM, Potts B, Kutzbach B, Yi H, Schlesinger LS (October 2002). "Mycobacterium tuberculosis-infected human macrophages exhibit enhanced cellular adhesion with increased expression of LFA-1 and ICAM-1 and reduced expression and/or function of complement receptors, FcgammaRII and the mannose receptor". Microbiology. 148 (Pt 10): 3161–71. doi:10.1099/00221287-148-10-3161. PMID 12368450.
• Chieppa M, Bianchi G, Doni A, Del Prete A, Sironi M, Laskarin G, Monti P, Piemonti L, Biondi A, Mantovani A, Introna M, Allavena P (November 2003). "Cross-linking of the mannose receptor on monocyte-derived dendritic cells activates an anti-inflammatory immunosuppressive program". J. Immunol. 171 (9): 4552–60. doi:10.4049/jimmunol.171.9.4552. PMID 14568928.
• Chan TL, Chan YW, Ho JW, Chan C, Chan AS, Chan E, Lam PW, Tse CW, Lee KC, Lau CW, Gwi E, Leung SY, Yuen ST (May 2004). "MSH2 c.1452-1455delAATG is a founder mutation and an important cause of hereditary nonpolyposis colorectal cancer in the southern Chinese population". Am. J. Hum. Genet. 74 (5): 1035–42. doi:10.1086/383591. PMC 1181966. PMID 15042510.
• Zhang J, Zhu J, Imrich A, Cushion M, Kinane TB, Koziel H (June 2004). "Pneumocystis activates human alveolar macrophage NF-kappaB signaling through mannose receptors". Infect. Immun. 72 (6): 3147–60. doi:10.1128/IAI.72.6.3147-3160.2004. PMC 415687. PMID 15155616.
• Napper CE, Taylor ME (October 2004). "The mannose receptor fails to enhance processing and presentation of a glycoprotein antigen in transfected fibroblasts". Glycobiology. 14 (10): 7C–12C. doi:10.1093/glycob/cwh109. PMID 15190005.
• Le Cabec V, Emorine LJ, Toesca I, Cougoule C, Maridonneau-Parini I (June 2005). "The human macrophage mannose receptor is not a professional phagocytic receptor". J. Leukoc. Biol. 77 (6): 934–43. doi:10.1189/jlb.1204705. PMID 15767290. S2CID 16432482.
• Zhang J, Tachado SD, Patel N, Zhu J, Imrich A, Manfruelli P, Cushion M, Kinane TB, Koziel H (September 2005). "Negative regulatory role of mannose receptors on human alveolar macrophage proinflammatory cytokine release in vitro". J. Leukoc. Biol. 78 (3): 665–74. doi:10.1189/jlb.1204699. PMID 16000387. S2CID 41060129.
• Kang PB, Azad AK, Torrelles JB, Kaufman TM, Beharka A, Tibesar E, DesJardin LE, Schlesinger LS (October 2005). "The human macrophage mannose receptor directs Mycobacterium tuberculosis lipoarabinomannan-mediated phagosome biogenesis". J. Exp. Med. 202 (7): 987–99. doi:10.1084/jem.20051239. PMC 2213176. PMID 16203868.
• Grupe A, Li Y, Rowland C, Nowotny P, Hinrichs AL, Smemo S, Kauwe JS, Maxwell TJ, Cherny S, Doil L, Tacey K, van Luchene R, Myers A, Wavrant-De Vrièze F, Kaleem M, Hollingworth P, Jehu L, Foy C, Archer N, Hamilton G, Holmans P, Morris CM, Catanese J, Sninsky J, White TJ, Powell J, Hardy J, O'Donovan M, Lovestone S, Jones L, Morris JC, Thal L, Owen M, Williams J, Goate A (January 2006). "A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease". Am. J. Hum. Genet. 78 (1): 78–88. doi:10.1086/498851. PMC 1380225. PMID 16385451.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.