Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase

Mannosyl-oligosaccharide 1,3-1,6-α-mannosidase, also known as Golgi α-mannosidase II, is an enzyme with systematic name (1→3)-(1→6)-mannosyl-oligosaccharide α-D-mannohydrolase.[1][2][3][4] It catalyses the hydrolysis of the terminal (1→3)- and (1→6)-linked α-D-mannose residues in the mannosyl-oligosaccharide Man5(GlcNAc)3.

Mannosyl-oligosaccharide 1,3-1,6-α-mannosidase
Identifiers
EC no.3.2.1.114
CAS no.82047-77-6
Alt. namesmannosidase II, exo-1,3-1,6-α-mannosidase, α-D-mannosidase II, α-mannosidase II, α-3,6-mannosidase, GlcNAc transferase I-dependent α1,3[α1,6]mannosidase, Golgi α-mannosidase II, ManII, 1,3(1,6)-α-D-mannosidase, 1,3-(1,6-)mannosyl-oligosaccharide α-D-mannohydrolase
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Search
PMCarticles
PubMedarticles
NCBIproteins

This enzyme is involved in the synthesis of glycoproteins. It is a key enzyme of N-linked glycan processing and is inhibited by small molecule swainsonine.[5]

References

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  1. ^ Harpaz N, Schachter H (May 1980). "Control of glycoprotein synthesis. Processing of asparagine-linked oligosaccharides by one or more rat liver Golgi α-D-mannosidases dependent on the prior action of UDP-N-acetylglucosamine: α-D-mannoside β 2-N-acetylglucosaminyltransferase I". The Journal of Biological Chemistry. 255 (10): 4894–902. PMID 6445359.
  2. ^ Tulsiani DR, Hubbard SC, Robbins PW, Touster O (Apr 1982). "α-D-Mannosidases of rat liver Golgi membranes. Mannosidase II is the GlcNAcMAN5-cleaving enzyme in glycoprotein biosynthesis and mannosidases Ia and IB are the enzymes converting Man9 precursors to Man5 intermediates". The Journal of Biological Chemistry. 257 (7): 3660–8. PMID 7061502.
  3. ^ Tulsiani DR, Opheim DJ, Touster O (May 1977). "Purification and characterization of α-D-mannosidase from rat liver Golgi membranes". The Journal of Biological Chemistry. 252 (10): 3227–33. PMID 863880.
  4. ^ Athanasopoulos VI, Niranjan K, Rastall RA (Mar 2005). "The production, purification and characterisation of two novel α-D-mannosidases from Aspergillus phoenicis". Carbohydrate Research. 340 (4): 609–17. doi:10.1016/j.carres.2005.01.005. PMID 15721331.
  5. ^ van den Elsen JM, Kuntz DA, Rose DR (2001). "Structure of Golgi α-mannosidase II: a target for inhibition of growth and metastasis of cancer cells". The EMBO Journal. 20 (12): 3008–3017. doi:10.1093/emboj/20.12.3008. PMC 150216. PMID 11406577.
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