Manuel Sistrunk (born June 16, 1947) is a former American football defensive lineman who played ten seasons in the National Football League (NFL). He played college football for Arkansas AM&N (now known as the University of Arkansas at Pine Bluff) and was drafted in the fifth round of the 1970 NFL draft.

Manny Sistrunk
No. 64, 79
Position:Defensive tackle
Defensive end
Personal information
Born: (1947-06-16) June 16, 1947 (age 77)
Montgomery, Alabama, U.S.
Height:6 ft 5 in (1.96 m)
Weight:269 lb (122 kg)
Career information
High school:Booker T. Washington (AL)
College:Arkansas-Pine Bluff
NFL draft:1970 / round: 5 / pick: 114
Career history
Stats at Pro Football Reference

He is a distant cousin to former NFL player Otis Sistrunk.