Margaret of Spain may refer to:
- Margaret of Austria, Queen of Spain (1584–1611), Queen of Spain as wife of Philip III of Spain and sister of Ferdinand II, Holy Roman Emperor
- Margaret Theresa of Spain (1651–1673), daughter of Philip IV of Spain
- Infanta Margarita, Duchess of Soria (born 1939), sister of Juan Carlos I of Spain
This disambiguation page lists articles about people with the same name.
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