Marie-Luce or Marie-Lucie is a French feminine given name. It may refer to :
- Marie-Luce Brasier-Clain (born 1959), French politician
- Marie-Luce Romanens (born 1973), Swiss orienteer
- Marie-Luce Penchard (born 1959), French politician
- Marie-Luce Waldmeier (born 1960), French alpine skier
- Marie-Lucie Morin, Canadian public official, lawyer, and former diplomat
- Marie-Lucie Tarpent (born 1941), French-born Canadian linguist