Mark Lee Mayer FRS[1][3] is scientist emeritus at the National Institutes of Health (NIH). His research investigates glutamate receptor ion channels, the major mediators of excitatory synapses in the brain. He has made numerous observations that have changed our view of receptor function and neurotransmission in the brain.[1] Major findings include discovery of the block of NMDA receptors by extracellular Mg and their high Ca permeability; analysis of the permeation and block of Ca permeable AMPA and kainate receptors by cytoplasmic polyamines; and structural studies on ligand binding, allosteric modulation, and gating using X-ray diffraction and cryoelectron microscopy.
Mark Mayer | |
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| Born | Mark Lee Mayer |
| Alma mater | University of Bristol (BSc) University of London (PhD) |
| Awards | Harkness Fellowship[1] |
| Scientific career | |
| Fields | Biophysics Ion channels Structural biology Glutamate receptors[2] |
| Institutions | National Institutes of Health |
| Thesis | Inhibitory synaptic mechanisms and transmitter candidates in the rostral hypothalamus of the rat (1980) |
| Website | irp |
Education
editMayer was educated at the University of Bristol, graduating with a BSc 1st class Hons in Pharmacology in 1977, and the University of London where he was awarded a PhD in Neuropharmacology in 1980.[4] He did postdoctoral training in biophysics at the NIH, and spent a year at Columbia University New York training in structural biology with Eric Gouaux.
Career and research
editMayer's research interests are in Biophysics, Glutamate receptors, Structural biology and Ion channels.[2][5][6]
Awards and honours
editMayer was awarded a Harkness Fellowship in 1980, a Beit Memorial Fellowship in 1982, and the Society for Neuroscience young investigator award in 1979. He was elected a Fellow of the Royal Society (FRS) in 2019 for "substantial contribution to the improvement of natural knowledge".[7]
References
edit- ^ a b c Anon (2019). "Dr Mark Mayer FRS". royalsociety.org. London: Royal Society. Archived from the original on 24 April 2019. One or more of the preceding sentences incorporates text from the royalsociety.org website where:
“All text published under the heading 'Biography' on Fellow profile pages is available under Creative Commons Attribution 4.0 International License.” --Royal Society Terms, conditions and policies at the Wayback Machine (archived 2016-11-11)
- ^ a b Mark Mayer publications indexed by Google Scholar
- ^ Mark Mayer publications from Europe PubMed Central
- ^ Mayer, Mark Lee (1980). Inhibitory synaptic mechanisms and transmitter candidates in the rostral hypothalamus of the rat. london.ac.uk (PhD thesis). The School of Pharmacy (University of London). OCLC 59986430. EThOS uk.bl.ethos.484097.
- ^ Mayer, Mark L.; Westbrook, Gary L.; Guthrie, Peter B. (1984). "Voltage-dependent block by Mg2+ of NMDA responses in spinal cord neurones". Nature. 309 (5965): 261–263. doi:10.1038/309261a0. ISSN 0028-0836. PMID 6325946.
- ^ Mayer, Mark L.; Westbrook, Gary L. (1987). "The physiology of excitatory amino acids in the vertebrate central nervous system". Progress in Neurobiology. 28 (3): 197–276. doi:10.1016/0301-0082(87)90011-6. ISSN 0301-0082.
- ^ Anon (2015). "Royal Society Elections". London: Royal Society. Archived from the original on 6 September 2015.
