Marmaduke is the surname of:

  • John S. Marmaduke (1833–1887), Confederate major general during the American Civil War and Governor of Missouri, son of Meredith Marmaduke
  • Meredith Marmaduke (1791–1864), American politician and Governor of Missouri
  • Thomas Marmaduke, early 17th century English explorer, sealer and whaler