Marsala is an Italian city on the island of Sicily.
Marsala can also refer to:
- Marsala Ship, a warship wreck in the harbor of Sicily
- Marsala wine
- Chicken marsala, an Italian-American dish made with the wine
- Marsala, fictional character in the animated series Exosquad
- Marsala (surname)
- S.S.D. Marsala Calcio, an Italian football club