Massie is a surname sometimes derived from the Scottish clan name Matheson. Notable people with the surname include:
- John Massie, Pipe Major; MBE 1931-2022
- Alex Massie (disambiguation), multiple people
- Allan Massie (born 1938), Scottish journalist and novelist
- Bob Massie (born 1947), Australian cricketer
- Edward Massie (1619–1674), English Parliament soldier in the English Civil War
- Elizabeth Massie, American author
- Eugene C. Massie (1861–1924), Virginia politician
- Hugh Massie (1854–1938), Australian cricketer
- Jack Massie (1890–1966), Australian cricketer
- John Massie (1842–1925), British theologian and politician
- Joseph Massie (economist) (died 1784), British political economist
- Joseph Massie (American football) (1871–1922), American football player and coach
- Matthew (born 1985) and Nicholas Massie (born 1989), American professional wrestlers collectively known as The Young Bucks
- Nathaniel Massie (1763–1813), American early Ohio Country frontier surveyor
- Peter Massie (1767–1840), Scottish planter
- Robert K. Massie (1929–2019), American historian
- Robert Lee Massie (1941–2001), American convicted murderer executed in California
- Robert Kinloch Massie (born 1956), American author
- Thalia Fortescue Massie (1911–1963), the figure at the centre of a Hawaiian murder trial
- Thomas Massie (burgess), (1675–1732) early Virginia politician and slaveowner
- William Massie (burgess), (1718-1751) early Virginia politician and slaveowner
- Thomas Massie (planter), (1747-1834) Continental Army officer and Virginia slaveowner
- Thomas Massie (born 1971), American politician
- Thomas Leeke Massie (1802–1898), admiral in the British Navy