Mastermind-like 3 (drosophila)

Mastermind-like 3 (Drosophila) is a protein that in humans is encoded by the MAML3 gene.

MAML3
Identifiers
Aliases	MAML3, CAGH3, ERDA3, GDN, MAM-2, MAM2, TNRC3, Mastermind-like 3, mastermind like transcriptional coactivator 3, mam-3
External IDs	OMIM: 608991; MGI: 2389461; HomoloGene: 41284; GeneCards: MAML3; OMA:MAML3 - orthologs
Gene location (Human) Chr. Chromosome 4 (human) Band 4q31.1 Start 139,716,753 bp End 140,154,184 bp
Gene location (Mouse) Chr. Chromosome 3 (mouse) Band 3|3 C Start 51,593,328 bp End 52,012,497 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in germinal epithelium corpus epididymis gingival epithelium skin of hip tail of epididymis parotid gland visceral pleura sural nerve parietal pleura caput epididymis Top expressed in paraxial mesoderm tail of embryo ureter genital tubercle female urethra placenta male urethra stroma of kidney ventricular zone lip More reference expression data BioGPS n/a
Gene ontology Molecular function transcription coactivator activity Cellular component nucleus nucleoplasm nuclear speck Biological process Notch signaling pathway transcription initiation from RNA polymerase II promoter regulation of transcription, DNA-templated transcription, DNA-templated positive regulation of transcription by RNA polymerase II positive regulation of transcription of Notch receptor target positive regulation of Notch signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55534 433586 Ensembl ENSG00000196782 ENSMUSG00000061143 UniProt Q96JK9 n/a RefSeq (mRNA) NM_018717 NM_001004176 RefSeq (protein) NP_061187 n/a Location (UCSC) Chr 4: 139.72 – 140.15 Mb Chr 3: 51.59 – 52.01 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Further reading

• Margolis RL, Abraham MR, Gatchell SB, Li SH, Kidwai AS, Breschel TS, Stine OC, Callahan C, McInnis MG, Ross CA (July 1997). "cDNAs with long CAG trinucleotide repeats from human brain". Human Genetics. 100 (1): 114–22. doi:10.1007/s004390050476. PMID 9225980. S2CID 25999127.
• Lin SE, Oyama T, Nagase T, Harigaya K, Kitagawa M (December 2002). "Identification of new human mastermind proteins defines a family that consists of positive regulators for notch signaling". The Journal of Biological Chemistry. 277 (52): 50612–20. doi:10.1074/jbc.M209529200. PMID 12386158.
• Hu Z, Shi Y, Mo X, Xu J, Zhao B, Lin Y, Yang S, Xu Z, Dai J, Pan S, Da M, Wang X, Qian B, Wen Y, Wen J, Xing J, Guo X, Xia Y, Ma H, Jin G, Yu S, Liu J, Zhou Z, Wang X, Chen Y, Sha J, Shen H (July 2013). "A genome-wide association study identifies two risk loci for congenital heart malformations in Han Chinese populations". Nature Genetics. 45 (7): 818–21. doi:10.1038/ng.2636. PMID 23708190. S2CID 7904277.
• Tonon G, Modi S, Wu L, Kubo A, Coxon AB, Komiya T, O'Neil K, Stover K, El-Naggar A, Griffin JD, Kirsch IR, Kaye FJ (February 2003). "t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway". Nature Genetics. 33 (2): 208–13. doi:10.1038/ng1083. PMID 12539049. S2CID 23417795.
• Wu L, Sun T, Kobayashi K, Gao P, Griffin JD (November 2002). "Identification of a family of mastermind-like transcriptional coactivators for mammalian notch receptors". Molecular and Cellular Biology. 22 (21): 7688–700. doi:10.1128/MCB.22.21.7688-7700.2002. PMC 135662. PMID 12370315.