Matthew Cooke or Matt Cooke may refer to:
- Matthew Cooke (entomologist) (1829–1887), California's first economic entomologist
- Matthew Cooke (fl. 1861), English Freemason and editor of the Matthew Cooke Manuscript
- Matthew Cooke (filmmaker) (born 1973), American film producer
- Matt Cooke (born 1978), Canadian ice hockey player
- Matt Cooke (cyclist) (born 1979), American cyclist
- Matt Cooke (journalist) (born 1982), British journalist working for BBC News