Mayzel is a Jewish surname. Notable people, with the surname include:
- Boris Mayzel (1907–1986), Soviet composer
- Nachman Mayzel (1887-1966), Russian-Jewish/American/Israeli Yiddish editor and literary critic
- Sergey Mayzel (1907–1955), Soviet physicist
- Wacław Mayzel (1847–1916), Polish histologist
Fictional characters
edit- Professor Mayzel (Spriggan) from Spriggan manga