Mazza is a surname of Italian origin. Notable people with the surname include:
- Benedetta Mazza (born 1989), Italian beauty queen, actress, television presenter and model
- Bruno Mazza, Italian footballer
- Chris Mazza, American baseball pitcher
- Cole Mazza (born 1995), American football player
- Cris Mazza, American novelist
- Damiano Mazza (artist), 16th century Italian painter
- Gianni Mazza (born 1944), Italian composer and conductor
- Giorgio Mazza, Italian hurdler
- Giuseppe Mazza (1817–1884), Italian painter
- Giuseppe Maria Mazza (1653–1741), Italian sculptor
- Joseph Mazza (1905–1993), American politician
- Marco Mazza, Italian long-distance runner
- Mario Mazza, Italian educator
- Pablo Mazza, Argentine footballer
- Paolo Mazza, Italian football manager
- Pier Filippo Mazza, Sammarinese footballer
- Raúl Mazza, Argentine painter
- Richard Mazza (1939–2024), American businessman and politician
- Robert Mazza, Judge of the Court of Appeal of the Supreme Court of Western Australia
- Salvador Mazza, Argentine physician and epidemiologist
- Tommaso del Mazza, 14th-century Florentine painter
- Valeria Mazza, Argentine fashion model
- Ventura Mazza (c. 1560 - 1638), Italian painter
- Viviana Mazza, Italian writer/journalist