Mazzola is an Italian surname. Notable people with the surname include:
- Alessandro Mazzola (footballer born 1969), Italian footballer
- Anna Mazzola British author
- Caterino Mazzolà, Italian poet and librettist
- Denia Mazzola, Italian operatic soprano
- Ferruccio Mazzola, Italian footballer
- Frank Mazzola, American film editor
- Girolamo Mazzola Bedoli (1500–1569), Italian painter
- Guerino Mazzola, Swiss mathematician
- Joey Mazzola, American guitarist
- José Altafini, Brazilian footballer who played under the name Mazzola
- Marissa Mazzola-McMahon, American film producer
- Parmigianino (1503–1540), Italian painter
- Rose Mazzola, American musician
- Sandro Mazzola, Italian footballer
- Valentino Mazzola, Italian footballer