McLain is a surname. Notable people with the surname include:
- Carrie M. McLain, American writer, teacher
- Denny McLain, American baseball player
- Ellen McLain, American voice actor
- Hardy McLain (born 1952), American hedge fund manager
- Jeremiah McLain Rusk, American politician, 15th governor of the state of Wisconsin
- Masey McLain, American actress
- Matt McLain, American baseball player
- Raymond S. McLain, American military general
- Tommy McLain, American singer
Fictional characters:
- Ember McLain, character from the animated series Danny Phantom
Other possible meanings
edit- McLain, Mississippi, United States
- McLain State Park, Michigan
- Big Jim McLain, a 1952 film starring John Wayne.
- Clan MacLaine of Lochbuie, a highland Scottish clan.