Meléndez is a common surname in the Spanish language. The variant is Melendez. It may refer to:
- Adolfo Meléndez (born 1884), Spanish military scientist
- Carlos Meléndez (disambiguation), multiple people
- Gerardo Meléndez, Puerto Rico-born scientist
- Juan Meléndez Valdés (born 1754), Spanish poet
- Jorge Meléndez (born 1871), 26th President of El Salvador
- María Meléndez (born 1951), Puerto Rican politician
- Rodrigo Meléndez (born 1977), Chilean football player